https://www.ovid.com/journals/nejm/abstract/10.1056/nejmcibr071461~cancer-regression-by-senescence?redirectionsource=fulltextview Senescence in tumours: evidence from mice and humans Manuel Collado 1 , Manuel Serrano 1 Author information Copyright and License information PMCID: PMC3672965 EMSID: EMS51925 PMID: 20029423 The publisher's version of this article is available at Nat Rev Cancer Preface Cellular senescence is a stress response that stably blocks proliferation and whose importance in cancer is increasingly recognized. Senescence is prevalent in premalignant tumours and progression to malignancy requires evading senescence. Malignant tumours, however, may still undergo senescence by interventions that restore tumour suppressors or inactivate oncogenes. Senescent tumour cells can be cleared by immune cells and this may result in efficient tumour regression. Standard chemotherapy also has the potential to induce senescence, whi...