https://articles.mercola.com/sites/articles/archive/2024/03/09/randle-cycle.aspx?cid_source=dnlsubstack&cid_medium=email&cid_content=art1Bttn&cid=20240309_SU Understanding the Randle Cycle Analysis by Dr. Joseph Mercola March 09, 2024 How Often Should You Poop? Playing an Instrument, Singing May Help Preserve Brain Health STORY AT-A-GLANCE Some in the keto and carnivore space argue that eating fats and carbs together will result in weight gain because of the Randle cycle, which serves as a switch that only allows your body to burn either fats or glucose, one at a time, not both together The Randle cycle refers to an antagonism between glucose and fats as fuel, which explains why you can become insulin resistant when you avoid carbohydrates If you’re in chronic ketosis, your tissues decrease their insulin sensitivity, which can lead to or contribute to insulin resistance A low-carb diet is best implemented as a temporary strategy to re...
https://www.ovid.com/journals/nejm/abstract/10.1056/nejmcibr071461~cancer-regression-by-senescence?redirectionsource=fulltextview Senescence in tumours: evidence from mice and humans Manuel Collado 1 , Manuel Serrano 1 Author information Copyright and License information PMCID: PMC3672965 EMSID: EMS51925 PMID: 20029423 The publisher's version of this article is available at Nat Rev Cancer Preface Cellular senescence is a stress response that stably blocks proliferation and whose importance in cancer is increasingly recognized. Senescence is prevalent in premalignant tumours and progression to malignancy requires evading senescence. Malignant tumours, however, may still undergo senescence by interventions that restore tumour suppressors or inactivate oncogenes. Senescent tumour cells can be cleared by immune cells and this may result in efficient tumour regression. Standard chemotherapy also has the potential to induce senescence, whi...