Skip to main content

senescent cell called zombie cells

AI Overview
This review explores the potential of inducing senescence in cancer cells and exploiting their unique features for cancer treatment, including selective eradication (senolysis) and immune system activation, along with the challenges and opportunities of a sequential "one-two punch" approach of pro-senescence followed by senolytic therapy. 
Senescence in Cancer Cells:
  • What is Senescence?
    Senescence is a cellular response to stress, characterized by a stable cell cycle arrest and changes in cell morphology and physiology. 
  • Senescence in Cancer:
    While often studied in non-cancer cells, cancer cells can also mount a senescence response. 
  • Inducing Senescence in Cancer:
    Various stressors, including DNA damage, oncogene activation, and certain drugs, can induce senescence in cancer cells. 
  • Distinctive Features of Senescent Cancer Cells:
    Senescent cancer cells exhibit a unique phenotype, including cell cycle arrest, changes in morphology (e.g., enlarged, flattened cells), and a senescence-associated secretory phenotype (SASP). 
  • Senolysis:
    Senescent cells can be selectively eradicated through senolytic therapy, which exploits their vulnerabilities. 
  • Immune System Activation:
    The SASP can activate the immune system, potentially leading to the clearance of senescent cancer cells. 
  • "One-Two Punch" Therapy:
    A sequential approach of inducing senescence (pro-senescence therapy) followed by senolytic therapy offers a promising strategy for cancer treatment. 
Challenges and Opportunities:
  • Challenges:
    The persistence of senescent cells and their potential to contribute to cancer development and metastasis are challenges that need to be addressed. 
  • Opportunities:
    Senescence-based therapies offer the potential for selective cancer cell eradication, immune system activation, and a reduction in the risk of recurrence. 
  • Exploiting senescence for the treatment of cancer - Nature
    Mar 3, 2022 — Abstract. Senescence is a cellular response to a variety of stress signals that is characterized by a stable withdrawal...
    Nature
  • Mechanisms of Cellular Senescence: Cell Cycle Arrest and ...
    Senescent cells can also develop morphological and structural changes, including an enlarged, flattened, multinucleated morphology...
    Frontiers
  • Review senescence in health and disease - ScienceDirect.com
    Jun 1, 2017 — Senescence is initiated as a response to a cellular insult, leading initially to a transient cell-cycle arrest, usually...
    ScienceDirect.com
  • Show all
This is for informational purposes only. For medical advice or diagnosis, consult a professional. Generative AI is experimental.

Comments

Popular posts from this blog

Might Biden be a Liar & Predator like McCarrick?

September 15, 2020   Everyone knows that sexual predator ex-cardinal Theodore McCarrick is a liar. His whole life was a lie of betrayal of the most sacred vows he took and the violation of the moral tenets of the Catholic faith which he desecrated. Most people don't realize that part of this desecration of lies included lying for "gravely sinful" Democrats like Joe Biden. McCarrick protected Biden when then head of the Congregation for the Doctrine of the Faith Cardinal Joseph Ratzinger (later to be Pope Benedict XVI) wrote that bishops were not to admit to Communion politicians like "gravely sinful" Biden who supports the killing of unborn babies. McCarrick lied for politicians like Biden by ignoring the important parts of the Ratzinger letter and told bishops not to ignore the Catholic Church law.  Last year, Fr. Robert Morey denied Holy Communion to the “gravely sinful” Biden following a "2004 decree signed jointly by the bishops of ...

The Biben Lying Machine: "Joe , do you know what else is a Sin besides Killing Babies? Lying... "

October 09, 2020   It appears that Joe Biden was even a lying machine in 2008 according to the post " Media Ignores Biden Repeatedly Lies During 'Meet the Press' Interview" on the Weasel Zippers website: Joe Biden Repeatedly Lies During "Meet the Press" Interview, Claims he Doesn't Support Taxpayer Funded Abortions.....   Joe, do you know what else is a sin besides killing babies? Lying... ... Joe Biden repeatedly made the claim in a Sunday interview on the NBC political show "Meet the Press" that he opposes taxpayer funding of abortions. However, a look at his voting record over the years reveals numerous instances where Barack Obama's pro-abortion running mate did exactly that. "I don't support public, public funding. I don't, because that flips the burden. That's then telling me I have to accept a different view," he said on the program. As recently as February, Biden voted against an amendmen...

Vox Cantoris vs. Aqua

The Catholic Monitor commenter Aqua had this to say to the Vox Cantoris website: Aqua said… Fred, your topic here reminds me of a dust-up, a few days ago, on Vox Cantoris. He asserted that it is our duty as Christians to wear masks to the Holy Sacrifice of the Mass if the government tells us we must, or they will close our Churches. My response to him was that I find it inconceivable that an orthodox Catholic, such as himself, would ever submit to unjust dictates from secular government over how we approach Our Lord in Holy Mass. My response to him was that the Mass belongs to Catholics and we decide, within the bounds of Tradition, and in accord with the Word of Jesus, how we conduct ourselves in Holy Mass. Only one authority prevails over Mass and that is our God and the Sacred Tradition given by Him to guide us in all times and places. Understand, there is nothing inherently wrong with wearing a mask to Mass. But there is EVERYTHING wrong with wearing a symbol...